Traffic along Route B in Randolph and Howard Counties will be reduced to one lane this week.
Crews will be patching asphalt from Route A in Randolph County west to Route 3 in Howard County.
The road will be one lane only between 6 a.m. and 6 p.m. They hope to finish the project on Friday.
MODoT encourages drivers to use caution and pay close attention when traveling in the area.
The work is weather dependent and could be delayed or rescheduled.