Members of the Maries County Sheriff's Office responded to a home on Highway 133 near Dixon, where an armed suspect was threatening to kill himself.
When deputies arrived at the scene the suspect came to the door with a weapon and threatened to kill the deputies. He then barricaded himself in the home.
Four rounds were fired from the house as the deputies waited for backup.
The standoff lasted around two hours before the Sheriff was able to take the suspect into custody.
The suspect had self-inflected gunshot wounds to his leg and the back of his head. He was airlifted to a local hospital for treatment.
"This was a dangerous scene," said Maries County Sheriff Chris Heitman. "I am glad no one was killed."
The Missouri State Highway Patrol responded to assist with the situation.